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synthesis of a 2-furylpyrazoline derivative using microwave irradiation使用微波辐射合成2-furylpyrazoline导数.pdf

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synthesis of a 2-furylpyrazoline derivative using microwave irradiation使用微波辐射合成2-furylpyrazoline导数

Molbank 2009, M613 OPEN ACCESS molbank ISSN 1422-8599 /journal/molbank Short Note Synthesis of a 2-Furylpyrazoline Derivative Using Microwave Irradiation Balapragalathan Thappali Jothikrishnan* and Suban Syed Shafi Department of Chemistry, Islamiah College, Vaniyambadi-635 751, Tamilnadu, India * Author to whom correspondence should be addressed; E-mail: bala.pragalathan@ Received: 10 May 2009 / Accepted: 14 July 2009 / Published: 10 August 2009 Abstract: A simple method for the synthesis of pyrazoline derivative containing furan moiety was developed. Thus, 5-(6-bromo- 1,3-benzodioxol-5-yl)-3-(2-furyl)-1-(3-methyl- phenyl)-4,5-dihydro-1H-pyrazole was synthesized using microwave irradiation and it was characterized by NMR, IR, and LCMS. Keywords: (2Z)-3-(6-bromo-1,3-benzodioxol-5-yl)-1-(2-furyl) prop-2-en-1-one; 3- tolylhydrazine hydrochloride; microwave Aryl furylpyrazolines exhibit antidepressant and anticonvulsant activities [1]. Pyrazolines can be synthesized by the reaction between chalcones (1) and arylhydrazines (2) using catalytic amounts of acetic acid in ethanol as solvent under reflux conditions [2] and acetic acid as a solvent [3]. In some cases bases like K CO [4] and Ba(OH) [5] were employed. We are hereby reporting a simple method 2 3 2 for synthesizing an aryl furylpyrazoline by a non-conventional method, using microwave conditions, which does not need any catalyst. The work-up procedure is simple and convenient. Molbank 2009