原创力文档synthesis of analogs of amathamide a and their preliminary antimicrobial activity合成类似物的amathamide及其初步的抗菌活性.pdfVIP
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synthesis of analogs of amathamide a and their preliminary antimicrobial activity合成类似物的amathamide及其初步的抗菌活性
Molecules 2005, 10, 295-301
molecules
ISSN 1420-3049
Synthesis of Analogs of Amathamide A and Their Preliminary
Antimicrobial Activity
Moisés Ramírez-Osuna 1, Daniel Chávez 1, Lourdes Hernández 2, Elias Molins 3, Ratnasamy
Somanathan 1 and Gerardo Aguirre 1,*
1 Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Apartado Postal 1166,
22000, Tijuana, B.C., México
2 Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F, México
3 Instituto de Ciencia de Materiales de Barcelona (CSIC), Campus de la UAB, 08193 Cerdanyola
(Barcelona), Spain
* Author to whom correspondence should be addressed. Tel.: (+52) 664 623-3772; Fax: (+52) 664
623-4043; E-mail: gaguirre@tectijuana.mx
Received: 20 August 2004; in revised form 6 January 2005 / Accepted: 7 January 2005 / Published:
31 January 2005
Abstract: Syntheses of three non-brominated analogs of amathamide A (1), a natural
alkaloid isolated from the Tasmanian marine bryozoan Amathia wilsoni , are described.
Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli,
Pseudomona aeruginosa, and Candida albicans was tested. Test results for amathamide
A (1) showed a weak activity against C. albicans and E. coli . The three non-natural
analogs 2-4 proved to be inactive compounds.
Keywords: Organic synthesis, Amathamide A, Antimicrobial activity.
Introduction
Amathamide A (1) is a brominated alkaloid isolated from the
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