synthesis of chalcones with anticancer activities合成化合物的抗癌活性.pdfVIP

Molecules 2012, 17, 6179-6195; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis of Chalcones with Anticancer Activities 1 2, 3 4 Suvitha Syam , Siddig Ibrahim Abdelwahab *, Mohammed Ali Al-Mamary and Syam Mohan 1 UPM-MAKNA Cancer Research Lab, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia; E-Mail: suvithaavs@ 2 Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mail: siddigroa@ 3 Department of Chemistry, Faculty of Science and Arts in Al-Mukhwah, Al-Baha University, Al-Baha 65431, Saudi Arabia; E-Mail: almamarym@ 4 Centre for Natural Products and Drug Discovery (CENAR), Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mail: syammohanm@ * Author to whom correspondence should be addressed; E-Mail: siddigroa@; Tel.: +603-7967-4909; Fax: +603-7967-4964. Received: 28 March 2012; in revised form: 20 April 2012 / Accepted: 27 April 2012/ Published: 25 May 2012 Abstract: Several chalcones were synthesized and their in vitro cytotoxicity against various human cell lines, including human breast adenocarcinoma cell line MCF-7, human lung adenocarcinoma cell line A549, human prostate cancer cell line PC3, human adenocarcinoma cell line HT-29 (colorectal cancer) and human normal