synthesis under microwave irradiation of [1,2,4]triazolo[3,4-b]？[1,3,4]thiadiazoles and other diazoles bearing indole moieties and their antimicrobial evaluation微波辐射下合成(1、2、4)triazolo(3、4 b)(1,3,4)thiadiazoles和其他二唑轴承吲哚及其抗菌半个评估.pdfVIP

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synthesis under microwave irradiation of [1,2,4]triazolo[3,4-b]？[1,3,4]thiadiazoles and other diazoles bearing indole moieties and their antimicrobial evaluation微波辐射下合成(1、2、4)triazolo(3、4 b)(1,3,4)thiadiazoles和其他二唑轴承吲哚及其抗菌半个评估.pdf

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synthesis under microwave irradiation of [1,2,4]triazolo[3,4-b]？[1,3,4]thiadiazoles and other diazoles bearing indole moieties and their antimicrobial evaluation微波辐射下合成(1、2、4)triazolo(3、4 b)(1,3,4)thiadiazoles和其他二唑轴承吲哚及其抗菌半个评估

Molecules 2011, 16, 8244-8256; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis under Microwave Irradiation of [1,2,4]Triazolo[3,4-b] [1,3,4]thiadiazoles and Other Diazoles Bearing Indole Moieties and Their Antimicrobial Evaluation Sobhi M. Gomha * and Sayed M. Riyadh Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt; E-Mail: riyadh1993@ (S.M.R.) * Author to whom correspondence should be addressed; E-Mail: s.m.gomha@; Tel.: +20-237-400-304; Fax: +20-225-685-799. Received: 23 August 2011; in revised form: 21 September 2011 / Accepted: 22 September 2011 / Published: 28 September 2011 Abstract: Microwave-assisted synthesis of some novel compounds, namely, 3-(2-methyl- 1H-indol-3-yl)-6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a,b was accomplished via bromination of 2-methyl-3-[4-(arylideneamino)-5-mercapto-4H-[1,2,4]triazol-3-yl]-1H- indoles 3a,b. Also, new [1,3,4]thiadiazoles 12a,b, [1,2,4]triazoles 15a,b and [1,3,4]oxadiazoles 19a,b, with indole moieties, were prepared by cyclization of 1-[(2-methyl-1H-indole)-3- carbonyl]thiosemicarbazides 8a,b under microwave irradiation using different reaction conditions. Moreover, reaction of acid hydrazide 7 with ethyl 2-(N-phenylhydrazono)-3- oxobutanoate (20) gave the respective phenylhydrazonopyrazole derivative 21 under the reaction conditions employed. The structures of the synthesized compounds were assigned