原创力文档systemic inflammatory response to cardiac surgery does female sex really protect系统性炎症反应心脏手术真的女性性保护.pdfVIP
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systemic inflammatory response to cardiac surgery does female sex really protect系统性炎症反应心脏手术真的女性性保护
Critical Care December 2001 Vol 5 No 6 Seghaye et al.
Commentary
Systemic inflammatory response to cardiac surgery: does female
sex really protect?
Marie-Christine Seghaye*, Ma Qing† and Götz von Bernuth†
*Department of Paediatric Cardiology and Congenital Heart Diseases, German Heart Centre, Munich, Germany
†Department of Paediatric Cardiology, Aachen University of Technology, Aachen, Germany
Correspondence: Marie-Christine Seghaye, seghaye@dhm.mhn.de
Published online: 6 November 2001
Critical Care 2001, 5:280-282
© 2001 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X)
See Research, page 343
Abstract
Sex hormones have important interactions with the immune system and modulate the inflammatory
response. In this regard, oestrogen inhibits the transcription of proinflammatory cytokines and confers
tissue protection in experimental models. On the basis of this evidence, Trotter et al. in this issue of
Critical Care addressed the question of whether, in children, female sex would protect against the
deleterious effects of cardiac operations with cardiopulmonary bypass by providing a favourable anti-
inflammatory cytokine balance. The observations made in that study suggest sex-related
immunomodulation and organ protection during cardiac surgery in the paediatric population. Prospective
trials conducted in large series, including sex hormone determination in neonates, infants and children
with congenital cardiac defects, are necessary to test this hypothesis. The verification of sex-related
intraoperative organ protection would provide new opportunities for preventing the uncontrolled systemic
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