synthesis and bioactivity of n-benzoyl-n-[5-(2-substituted phenyl)-2-furoyl] semicarbazide derivatives的合成和生物活性n-benzoyl-n -[5 -(2取代苯基)2-furoyl]氨基脲衍生品.pdfVIP

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synthesis and bioactivity of n-benzoyl-n-[5-(2-substituted phenyl)-2-furoyl] semicarbazide derivatives的合成和生物活性n-benzoyl-n -[5 -(2取代苯基)2-furoyl]氨基脲衍生品.pdf

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synthesis and bioactivity of n-benzoyl-n-[5-(2-substituted phenyl)-2-furoyl] semicarbazide derivatives的合成和生物活性n-benzoyl-n -[5 -(2取代苯基)2-furoyl]氨基脲衍生品

Molecules 2010, 15, 4267-4282; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Bioactivity of N-Benzoyl-N -[5-(2-substituted phenyl)-2-furoyl] Semicarbazide Derivatives Zining Cui 1, Yun Ling 1, Baoju Li 2, Yongqiang Li 1, Changhui Rui 1, Jingrong Cui 3, Yanxia Shi 2 and Xinling Yang 1,* 1 Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China; E-Mails: ziningcui@ (Z.C.); lyun@ (Y.L.); lyq@ (Y.L.); chrui@ (C.R.) 2 Institute of Vegetables and Flowers, Chinese Academy of Agricultural Science, Beijing 100081, China; E-Mails: libaoj126.com (B.L.); shiyanxia813@163.com (Y.S.) 3 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing 100083, China; E-Mail: jrcui@ (J.C.) * Author to whom correspondence should be addressed; E-Mail: yangxl@; Tel.: +86-10-6273-2223; Fax: +86-10-6273-2223. Received: 5 May 2010; in revised form: 31 May 2010 / Accepted: 2 June 2010 / Published: 11 June 2010 Abstract: In order to find novel chitin synthesis inhibitors (CSIs) with good activity, benzoylphenylurea, a typical kind of CSIs, was chosen as the lead compound and 15 novel derivatives containing furan moieties were designed by converting the urea linkage of benzoylphenylureas into a semicarbazide and changing the aniline part into furoyl group