synthesis and biological activities of a 3-azido analogue of doxorubicin against drug-resistant cancer cells3 叠氮基类似物的合成和生物活性的阿霉素对耐药肿瘤细胞.pdfVIP

Int. J. Mol. Sci. 2012, 13, 3671-3684; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Synthesis and Biological Activities of a 3-Azido Analogue of Doxorubicin Against Drug-Resistant Cancer Cells Shuwen Yu 1,2,3, Guisheng Zhang 4, Wenpeng Zhang 2, Huanhua Luo 3, Liyun Qiu 3, Qingfeng Liu 4, Duxin Sun 5, Peng-George Wang 2,6,* and Fengshan Wang 1,* 1 School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; E-Mail: yushuwen@ 2 Department of Chemistry and Biochemistry, The Ohio State University, Ohio 43210, USA; E-Mail: zhangwenpeng@ 3 Jinan Central Hospital Affiliated to Shandong University, Jinan 250011, China; E-Mails: zxyylhh@163.com (H.L.); qiuliyun7777@163.com (L.Q.) 4 College of Chemistry and Environmental Sciences, Henan Normal University, Xinxiang 453002, China; E-Mails: zgs@ (G.Z.); greendiv@ (Q.L.) 5 College of Pharmacy, The University of Michigan, Michigan 48109, USA; E-Mail: duxins@ 6 College of Pharmacy, Nan Kai University, Tianjin 300071, China * Authors to whom correspondence should be addressed; E-Mails: pwang@ (P.-G.W.); fswang@ (F.W.); Tel.: +86-22-2350-6290 (P.-G.W.); +86-531-8838-2589 (F.W.); Fax: +86-22-2350-7760 (P.-G.W.); +86-531-8838-2548 (F.W.). Received: 13 February 2012; in revised form: 7 March 2012 / Accepted: 13 March 2012 / Published: 19 March 2012 Abstract: Doxorubicin (DOX), an anthracycline antibiotic, is one of the most active anticancer che