successful salvage therapy with daptomycin for osteomyelitis caused by methicillin-resistant staphylococcus aureus in a renal transplant recipient with fabry-anderson disease与daptomycin成功抢救治疗耐甲氧西林金黄色葡萄球菌引起的骨髓炎在肾移植接受者fabry-anderson疾病.pdfVIP

Polilli et al. Annals of Clinical Microbiology and Antimicrobials 2012, 11:6 /content/11/1/6 CASE REPORT Open Access Successful salvage therapy with Daptomycin for osteomyelitis caused by methicillin-resistant Staphylococcus aureus in a renal transplant recipient with Fabry-Anderson disease 1 2 3 3 1 1 Ennio Polilli , Tamara Ursini , Elena Mazzotta , Federica Sozio , Vincenzo Savini , Domenico D’Antonio , Michelino Barbato4, Augusta Consorte3 and Giustino Parruti3,5* Abstract Daptomycin is licensed in adults for the management of Staphylococcus aureus methicillin-resistant infections, including bone and skin complicated infections. We describe for the first time its use in a renal transplant recipient for Fabry-Anderson Disease with right heel osteomyelitis. The patient was unresponsive to first-line Teicoplanin and second-line Tigecycline, whereas he was successfully treated with third-line Daptomycin monotherapy at 4 mg/Kg/ qd for 4 weeks. Local debridement was performed in advance of each line of treatment. Keywords: Methicillin-resistant Staphylococcus aureus, Osteomyelitis, Daptomycin, Salvage therapy, Antibiotic therapy Background successfully treated with third-line Daptomycin in a Vancomycin, the first-line antibiotic choice for bone and renal transplant recipient for Fabry-Anderson Disease joint infections caused by grampositive bacteria, has (FAD). been reported with declining rates of efficacy against methicillin resistant Staphylococcus aureus (MRSA) iso- Case presentation lates [1]. The treatment of osteomyelitis, septic arthritis A 38-year-old patient, dia