原创力文档synthesis and biological activity of some new pyrazoline and pyrrolo[3,4-c]pyrazole-4,6-dione derivatives reaction of nitrilimines with some dipolarophiles合成和生物活性的一些新的pyrazoline和pyrrolo[3上]pyrazole-4 6-dione衍生品与一些dipolarophiles nitrilimines反应.pdfVIP
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synthesis and biological activity of some new pyrazoline and pyrrolo[3,4-c]pyrazole-4,6-dione derivatives reaction of nitrilimines with some dipolarophiles合成和生物活性的一些新的pyrazoline和pyrrolo[3上]pyrazole-4 6-dione衍生品与一些dipolarophiles nitrilimines反应
Molecules 2008, 13, 1011-1024
molecules
ISSN 1420-3049
© 2008 by MDPI
/molecules
Full Paper
Synthesis and Biological Activity of Some New Pyrazoline and
Pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives: Reaction of
Nitrilimines with Some Dipolarophiles
Nada M. Abunada 1,*, Hamdi M. Hassaneen 2, Nadia G. Kandile 3 and Omar A. Miqdad 1
1 Department of Chemistry, Faculty of Applied Sciences, Al-Aqsa University, 76888 Gaza, Palestine;
E-mail: miqdadomar@ (O. A. Miqdad)
2 Department of Chemistry, Faculty of Science, Cairo University, Egypt; E-mail:
hamdi_251@ (H. M. Hassaneen)
3 Department of Chemistry, University College for Women, Ain Shams University, Heliopolis, Cairo,
Egypt; E-mail: nadiaghk@ (N. G. Kandile)
*Author to whom correspondence should be addressed; E-mail: nadanadannrs@.
Received: 8 April 2008; in revised form: 22 April 2008 / Accepted: 22 April 2008 / Published: 29 April
2008
Abstract: Several 1,3-diaryl-5-(cyano-, aminocarbonyl- and ethoxycarbonyl-)-2-
pyrazoline, pyrrolo[3,4-c]pyrazole-4,6-dione and 1,3,4,5-tetraaryl-2-pyrazoline derivatives
were prepared by the reaction of nitrilimine with different dipolarophilic reagents. The new
compounds were characterized using IR, 1H-NMR, 13C-NMR and mass spectra. Biological
screening of some compounds is reported.
Keywords: Pyrazoline, pyrrolo[3,4-c]pyrazole-4,6-dione, nitrilimine, dipolarophile,
biological activity.
Introduction
Considerable attention has been focused on pyrazolines and substituted pyrazolines due to their
interesting biologic
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