t cell subsets in hiv infected patients after successful combination antiretroviral therapy impact on survival after 12 years在艾滋病毒感染患者t细胞亚群成功联合抗逆转录病毒疗法对生存了12年的影响.pdfVIP

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t cell subsets in hiv infected patients after successful combination antiretroviral therapy impact on survival after 12 years在艾滋病毒感染患者t细胞亚群成功联合抗逆转录病毒疗法对生存了12年的影响.pdf

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t cell subsets in hiv infected patients after successful combination antiretroviral therapy impact on survival after 12 years在艾滋病毒感染患者t细胞亚群成功联合抗逆转录病毒疗法对生存了12年的影响

T Cell Subsets in HIV Infected Patients after Successful Combination Antiretroviral Therapy: Impact on Survival after 12 Years ¨ 1 2 1 2 Frederikke Falkencrone Ronsholt *, Sisse Rye Ostrowski , Terese Lea Katzenstein , Henrik Ullum , Jan Gerstoft 1 1 Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark, 2 Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark Abstract Objectives: Immune activation is decreased by combination antiretroviral therapy (cART) in patients infected with human immunodeficiency virus (HIV), but residual activation remains and has been proposed as a cause of premature aging and death, but data are lacking. We analyzed the relationship between T-cell subsets after 18 months of cART and overall survival during 12 years of follow up. Methods: A cohort of 101 HIV infected patients who had undetectable plasma HIV after starting cART was included in 1997– 1998. T cell subsets were analyzed by flowcytometry after 18 months of cART. Relation to survival was calculated using Kaplan-Meier curves and multiple Cox regression. Results: Seventeen patients died during the observation period. The leading causes of death were non-AIDS cancer and cardiovascular disease. Higher levels of CD8 memory T cells (CD8+,CD45RO+,CD45RA-) showed a significant beneficiary effect on survival, HR of 0.95 (95% confidence interval 0.91–0.99, P = 0.016) when adjusted for age, nadir CD4 count, CD4 count, and AIDS and hepatitis C status. T cell activation was not associated with incre