targeting bone remodeling by isoflavone and 3,3′-diindolylmethane in the context of prostate cancer bone metastasis针对骨重塑的异黄酮和3、3u2032-diindolylmethane在前列腺癌骨转移的背景下.pdfVIP
- 1、本文档共11页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
targeting bone remodeling by isoflavone and 3,3′-diindolylmethane in the context of prostate cancer bone metastasis针对骨重塑的异黄酮和3、3u2032-diindolylmethane在前列腺癌骨转移的背景下
Targeting Bone Remodeling by Isoflavone and 3,3 9-
Diindolylmethane in the Context of Prostate Cancer
Bone Metastasis
1 1 1 1 1,2
Yiwei Li , Dejuan Kong , Aamir Ahmad , Bin Bao , Fazlul H. Sarkar *
1 Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America,
2 Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
Abstract
Prostate cancer (PCa) bone metastases have long been believed to be osteoblastic because of bone remodeling leading to
the formation of new bone. However, recent studies have shown increased osteolytic activity in the beginning stages of PCa
bone metastases, suggesting that targeting both osteolytic and osteoblastic mediators would likely inhibit bone
remodeling and PCa bone metastasis. In this study, we found that PCa cells could stimulate differentiation of osteoclasts
and osteoblasts through the up-regulation of RANKL, RUNX2 and osteopontin, promoting bone remodeling. Interestingly,
we found that formulated isoflavone and 3,39-diindolylmethane (BR-DIM) were able to inhibit the differentiation of
osteoclasts and osteoblasts through the inhibition of cell signal transduction in RANKL, osteoblastic, and PCa cell signaling.
Moreover, we found that isoflavone and BR-DIM down-regulated the expression of miR-92a, which is known to be
associated with RANKL signaling, EMT and cancer progression. By pathway and network analysis, we also observed the
regulatory effects of isoflavone and BR-DIM on multiple signaling pathways s
您可能关注的文档
- synthesis and structural characterization of the sodium salt of a new sulfonate-containing water soluble n-donor ligand? self-assembly in the solid state by π?π stacking interactions钠盐的合成和结构表征一个新的sulfonate-containing水溶性n-donor配体自组装在固态ππ堆积相互作用.pdf
- synthesis and structural characterization of the 5-(2-haloethyl)pyrimidines – hydrogen-bonded chains in α-(1-carbamyliminomethylene)-γ-butyrolactone的合成和结构表征5 -氢键链(2-haloethyl)嘧啶-α-(1-carbamyliminomethylene)-γ-butyrolactone.pdf
- synthesis and structural characterization of 1-[2-(5-nitro-1h-indol-2-yl)phenyl]methylpyridinium chloride合成和结构特征1 -[2 -(5-nitro-1h-indol-2-yl)苯基]methylpyridinium氯.pdf
- synthesis and reactivity of [1,2,4]triazolo-annelated quinazolines的合成和反应(1、2、4)triazolo-annelated喹唑啉.pdf
- synthesis and structure of bis(dibutyldithiocarbamate)zinc(ii) zn2[(n-bu)2ncss]4bis(dibutyldithiocarbamate)的合成和结构锌(ii)zn2[(n-bu)2摘要]4.pdf
- synthesis and study of novel coumarin derivatives potentially utilizable as memory media合成和研究新型香豆素衍生物潜在可利用的记忆的媒体.pdf
- synthesis and theoretical study of a new type of pentacyclic bis-benzothiazolium compound合成和理论研究的一种新型的五环的bis-benzothiazolium化合物.pdf
- synthesis and structure of d3h-symmetric triptycene trimaleimide合成和结构d3h-symmetric triptycene trimaleimide.pdf
- synthesis and structure-activity correlation studies of metal complexes of α-n-heterocyclic carboxaldehyde thiosemicarbazones in shewanella oneidensis金属配合物的合成及构效关系研究α-n-heterocyclic carboxaldehyde thiosemicarbazones在shewanella oneidensis.pdf
- synthesis and structure of a sodium complex of an aromatic β-diketone and pyrazolylpyridine钠的合成和结构复杂的芳香β-diketone pyrazolylpyridine.pdf
- targeting death receptor trail-r2 by chalcones for trail-induced apoptosis in cancer cells目标死亡受体trail-r2为trail-induced类化合物在肿瘤细胞凋亡.pdf
- targeting drosophila eye development针对果蝇眼睛的发展.pdf
- targeting amp-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation针对在脂肪细胞活化蛋白激酶调节与肥胖相关的adipokine生产与胰岛素抵抗和乳腺癌细胞增殖有关.pdf
- targeting dna-pkcs and atm with mir-101 sensitizes tumors to radiation针对dna-pkcs和atm mir - 101肿瘤辐射处于敏感状态.pdf
- targeting cea in pancreas cancer xenografts with a mutated scfv-fc antibody fragment针对东航在异种移植胰腺癌症突变scfv-fc抗体片段.pdf
- targeting cell entry of enveloped viruses as an antiviral strategy针对细胞进入包膜病毒的抗病毒策略.pdf
- targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism针对osteopenic老鼠和调节骨缓解骨关节炎软骨分解代谢.pdf
- targeting egfr induced oxidative stress by parp1 inhibition in glioblastoma therapy针对parp1抑制表皮生长因子受体诱导氧化应激的胶质母细胞瘤的治疗.pdf
- targeting fragile x针对脆性x.pdf
- targeting fgfr4 inhibits hepatocellular carcinoma in preclinical mouse models针对fgfr4抑制肝细胞癌在临床前小鼠模型.pdf
文档评论(0)