synthesis and structural characterization of 1-[2-(5-nitro-1h-indol-2-yl)phenyl]methylpyridinium chloride合成和结构特征1 -[2 -(5-nitro-1h-indol-2-yl)苯基]methylpyridinium氯.pdfVIP

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synthesis and structural characterization of 1-[2-(5-nitro-1h-indol-2-yl)phenyl]methylpyridinium chloride合成和结构特征1 -[2 -(5-nitro-1h-indol-2-yl)苯基]methylpyridinium氯.pdf

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synthesis and structural characterization of 1-[2-(5-nitro-1h-indol-2-yl)phenyl]methylpyridinium chloride合成和结构特征1 -[2 -(5-nitro-1h-indol-2-yl)苯基]methylpyridinium氯

Molecules 2011, 16, 7627-7633; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Synthesis and Structural Characterization of 1-[2-(5-Nitro-1H-indol-2- yl)phenyl]methylpyridinium Chloride John B. Bremner 1,*, Siritron Samosorn 2, Brian W. Skelton 3 and Allan H. White 3 1 School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia 2 Department of Chemistry, Srinakharinwirot University, Bangkok 10110, Thailand 3 School of Biomedical, Biomolecular and Chemical Sciences, Chemistry M313, The University of Western Australia, Crawley, W.A. 6009, Australia * Author to whom correspondence should be addressed; E-Mail: john_bremner@.au; Tel.: +612 Fax: +612 Received: 29 July 2011; in revised form: 22 August 2011 / Accepted: 25 August 2011 / Published: 6 September 2011 Abstract: In the course of studies on hybrid antibacterials incorporating 2-aryl-5-nitro-1H- indole moieties as potential bacterial NorA efflux pump inhibitors, the compound 1-[2-(5- nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride (2) was synthesized and structurally characterized. This pyridinium chloride salt crystallized in the monoclinic space group P21/c with the following unit cell dimensions: a 10.274(3) Å, b 13.101(4) Å, c 13.439(4) 3 Å, β 107.702(7)°, V 1723.2(9) Å , Z (f.u.) = 4; R 1 = 0.048, and wR2 = 0.13. Of interest in the single crystal X-ray structure is the (intramolecular) disposition of the pyridinium p