原创力文档surface engineering for bone implants a trend from passive to active surfaces表面工程对骨植入这一趋势从被动到主动的表面.pdfVIP
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surface engineering for bone implants a trend from passive to active surfaces表面工程对骨植入这一趋势从被动到主动的表面
Coatings 2012, 2, 95-119; doi:10.3390/coatings2030095
OPEN ACCESS
coatings
ISSN 2079-6412
/journal/coatings/
Review
Surface Engineering for Bone Implants: A Trend from Passive
to Active Surfaces
Ruggero Bosco, Jeroen Van Den Beucken, Sander Leeuwenburgh and John Jansen *
Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen 6525,
The Netherlands; E-Mails: r.bosco@dent.umcn.nl (R.B.); j.vandenbeucken@dent.umcn.nl (J.V.D.B.);
s.leeuwenburgh@dent.umcn.nl (S.L.)
* Author to whom correspondence should be addressed; E-Mail: j.jansen@dent.umcn.nl;
Tel.: +31-0-24-361-4006; Fax: +31-0-24-361-4657.
Received: 15 May 2012; in revised form: 7 June 2012 / Accepted: 19 June 2012 /
Published: 2 July 2012
Abstract: The mechanical and biological properties of bone implants need to be optimal to
form a quick and firm connection with the surrounding environment in load bearing
applications. Bone is a connective tissue composed of an organic collagenous matrix, a fine
dispersion of reinforcing inorganic (calcium phosphate) nanocrystals, and bone-forming
and -degrading cells. These different components have a synergistic and hierarchical
structure that renders bone tissue properties unique in terms of hardness, flexibility and
regenerative capacity. Metallic and polymeric materials offer mechanical strength and/or
resilience that are required to simulate bone tissue in load-bearing applications in terms of
maximum loa
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