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the argonaute protein familyargonaute蛋白家族
Protein family review
TThhee AArrggoonnaauuttee pprrootteeiinn ffaammiillyy
Julia Höck and Gunter Meister
Address: Center for Integrated Protein Science Munich (CIPSM), Laboratory of RNA Biology, Max Planck Institute of Biochemistry, Am
Klopferspitz, 82152 Martinsried, Germany.
Correspondence: Gunter Meister. Email: meister@biochem.mpg.de
Published: 26 February 2008
Genome BBiioollooggyy 2008, 99::210 (doi:10.1186/gb-2008-9-2-210)
The electronic version of this article is the complete one and can be
found online at /2008/9/2/210
© 2008 BioMed Central Ltd
SSuummmmaarryy
Argonaute proteins were first discovered genetically, and extensive research in the past few years
has revealed that members of the Argonaute protein family are key players in gene-silencing
pathways guided by small RNAs. Small RNAs such as short interfering RNAs (siRNAs),
microRNAs (miRNAs) or Piwi-interacting RNAs (piRNAs) are anchored into specific binding
pockets and guide Argonaute proteins to target mRNA molecules for silencing or destruction.
Various classes of small RNAs and Argonaute proteins are found in all higher eukaryotes and have
important functions in processes as diverse as embryonic development, cell differentiation and
transposon silencing. Argonaute proteins are evolutionarily conserved and can be phylogenetically
subdivided into the Ago subfamily and the Piwi subfamily. Ago proteins are ubiquitously expressed
and bind to siRNAs or miRNAs to guide post-transcriptional gene silencing either by
destabilization of the mRNA or by translational repression. The
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