原创力文档the cerebrospinal fluid proteome in hiv infection change associated with disease severity艾滋病毒感染的脑脊液蛋白质组变化与疾病严重程度有关.pdfVIP
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the cerebrospinal fluid proteome in hiv infection change associated with disease severity艾滋病毒感染的脑脊液蛋白质组变化与疾病严重程度有关
Angel et al. Clinical Proteomics 2012, 9:3
/content/9/1/3 CLINICAL
PROTEOMICS
RESEARCH Open Access
The cerebrospinal fluid proteome in HIV infection:
change associated with disease severity
1 1 2,5 1 3 2
Thomas E Angel , Jon M Jacobs , Serena S Spudich , Marina A Gritsenko , Dietmar Fuchs , Teri Liegler ,
4 1 2 1*
Henrik Zetterberg , David G Camp II , Richard W Price and Richard D Smith
* Correspondence: rds@ Abstract
1Biological Sciences Division, Pacific
Northwest National Laboratory, Background: Central nervous system (CNS) infection is a nearly universal feature of
Richland, WA, USA
Full list of author information is untreated systemic HIV infection with a clinical spectrum that ranges from chronic
available at the end of the article asymptomatic infection to severe cognitive and motor dysfunction. Analysis of
cerebrospinal fluid (CSF) has played an important part in defining the character of
this evolving infection and response to treatment. To further characterize CNS HIV
infection and its effects, we applied advanced high-throughput proteomic methods
to CSF to identify novel proteins and their changes with disease progression and
treatment.
Results: After esta
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