the ctx-m-15-producing escherichia coli clone o25b h4-st131 has high intestine colonization and urinary tract infection abilitiesctx-m-15-producing大肠杆菌克隆o25b h4-st131高肠殖民和尿路感染能力.pdfVIP
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the ctx-m-15-producing escherichia coli clone o25b h4-st131 has high intestine colonization and urinary tract infection abilitiesctx-m-15-producing大肠杆菌克隆o25b h4-st131高肠殖民和尿路感染能力
The CTX-M-15-Producing Escherichia coli Clone O25b:
H4-ST131 Has High Intestine Colonization and Urinary
Tract Infection Abilities
1,2 2,3 4,5 4,6 7
Sophie Vimont *, Anders Boyd , Alexandre Bleibtreu , Marcelle Bens , Jean-Michel Goujon ,
Louis Garry4,5, Olivier Clermont4,5, Erick Denamur4,5, Guillaume Arlet1,2, Alain Vandewalle4,6
ˆ ´ ´
1 AP-HP, Hopitaux Universitaires Est Parisien - site Tenon, Service de Bacteriologie, Paris, France, 2 Universite Paris 6 - Pierre et Marie Curie, Paris, France, 3 INSERM U707,
´ ´ ´
Paris, France, 4 Universite Paris Diderot, Sorbonne Paris Cite, Paris, France, 5 INSERM U722, Paris, France, 6 INSERM U773, Paris, France, 7 Unite de Pathologie
´ ´
Ultrastructurale et Experimentale, Centre Hospitalier et Universitaire de Poitiers; Universite de Poitiers, Poitiers, France
Abstract
Increasing numbers of pyelonephritis-associated uropathogenic Escherichia coli (UPEC) are exhibiting high resistance to
antibiotic therapy. They include a particular clonal group, the CTX-M-15-producing O25b:H4-ST131 clone, which has been
shown to have a high dissemination potential. Here we show that a representative isolate of this E. coli clone, referred to as
TN03, has enhanced metabolic capacities, acts as a potent intestine- colonizing strain, and displays the typical features of
UPEC strains. In a modified streptomycin-treated mouse mode
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