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the dual role of inflammation in colon carcinogenesis结肠炎症在致癌作用的双重角色
Int. J. Mol. Sci. 2012, 13, 11071-11084; doi:10.3390/ijms130911071
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
The Dual Role of Inflammation in Colon Carcinogenesis
Giovanni Monteleone, Francesco Pallone and Carmine Stolfi *
Department of Systems Medicine, University of Rome “Tor Vergata”, Via Montpellier 1,
Rome 00133, Italy; E-Mails: gi.monteleone@med.uniroma2.it (G.M.); pallone@uniroma2.it (F.P.)
* Author to whom correspondence should be addressed; E-Mail: carmine.stolfi@uniroma2.it;
Tel.: +39-06-7259-6158; Fax: +39-06-7259-6391.
Received: 1 August 2012; in revised form: 28 August 2012 / Accepted: 28 August 2012 /
Published: 6 September 2012
Abstract: Chronic inflammation characterizing patients with inflammatory bowel disease
(IBD) represents a major risk factor for the development of colorectal cancer. Mechanisms
underlying this neoplastic transformation are not fully understood though studies in
experimental models of colon carcinogenesis suggest that inflammatory cell-derived
cytokines either directly or indirectly stimulate the uncontrolled growth of cancer cells.
Nevertheless, under specific inflammatory conditions, immune cells can boost an
anti-tumor immune response with the down-stream effect of eliminating dysplastic and
cancerous cells. This review outlines the beneficial and detri
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