原创力文档the effectiveness of individual interpersonal psychotherapy as a treatment for major depressive disorder in adult outpatients a systematic review个人人际关系心理治疗的有效性作为一个治疗重度抑郁症在成人门诊系统回顾.pdfVIP
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the effectiveness of individual interpersonal psychotherapy as a treatment for major depressive disorder in adult outpatients a systematic review个人人际关系心理治疗的有效性作为一个治疗重度抑郁症在成人门诊系统回顾
van Hees et al. BMC Psychiatry 2013, 13:22
/1471-244X/13/22
RESEARCH ARTICLE Open Access
The effectiveness of individual interpersonal
psychotherapy as a treatment for major
depressive disorder in adult outpatients:
a systematic review
Madelon L J M van Hees1*, Thomas Rotter1,2, Tim Ellermann3 and Silvia M A A Evers1,4
Abstract
Background: This systematic review describes a comparison between several standard treatments for major
depressive disorder (MDD) in adult outpatients, with a focus on interpersonal psychotherapy (IPT).
Methods: Systematic searches of PubMed and PsycINFO studies between January 1970 and August 2012 were
performed to identify (C-)RCTs, in which MDD was a primary diagnosis in adult outpatients receiving individual IPT
as a monotherapy compared to other forms of psychotherapy and/or pharmacotherapy.
Results: 1233 patients were included in eight eligible studies, out of which 854 completed treatment in outpatient
facilities. IPT combined with nefazodone improved depressive symptoms significantly better than sole nefazodone,
while undefined pharmacotherapy combined with clinical management improved symptoms better than sole IPT.
IPT or imipramine hydrochloride with clinical management showed a better outcome than placebo with clinical
management. Depressive symptoms were reduced more in CBASP (cognitive behavioral analysis system of
psychotherapy) patients in comparison with IPT patients, while IPT reduced symptoms better than usual care and
wait list condition.
Conclusions: The differences between treatment effects are very small and often they are not significant.
Psychotherapeutic treatments such as IPT and CBT, and/or pharmacotherapy are recommended as first-line
treatments for depressed adult outpatients, without favoring one of them, although the individual preferences of
patients sh
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