原创力文档the effects of polyunsaturated fatty acids in alcohol dependence treatment - a double-blind, placebo-controlled pilot study多不饱和脂肪酸在治疗酒精依赖的影响,双盲,安慰剂对照试验研究.pdfVIP
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the effects of polyunsaturated fatty acids in alcohol dependence treatment - a double-blind, placebo-controlled pilot study多不饱和脂肪酸在治疗酒精依赖的影响,双盲,安慰剂对照试验研究
Fogaça et al. BMC Clinical Pharmacology 2011, 11:10
/1472-6904/11/10
RESEARCH ARTICLE Open Access
The effects of polyunsaturated fatty acids in
alcohol dependence treatment - a double-blind,
placebo-controlled pilot study
1 2 1 3*
Marina N Fogaça , Ruth F Santos-Galduróz , Jaqueline K Eserian and José Carlos F Galduróz
Abstract
Background: The lipid fraction of cell membranes consists of polyunsaturated fatty acids (PUFAS), and chronic
alcohol use alters it, modifying its permeability, what might contribute for the dysfunctional metabolism observed
in the central nervous system of alcohol dependent patients. Therefore, the supplementation of PUFAS can be an
important adjuvant in alcoholism treatment.
Methods: This was a placebo controlled, double blind, randomized study where, 80 alcohol dependent patients,
according to DSM-IV, were allocated in four groups with 20 patient each: ‘PUFAS’, ‘Naltrexone’, ‘Naltrexone +
PUFAS’ and ‘Placebo’. Those substances were administered for 90 days and scales were applied to assess patients
craving (OCDS) and alcohol dependence severity (SADD) at baseline and after 90 days. PUFAS serum levels were
assessed before and after treatment by high performance liquid chromatography assay.
Results: Forty-three patients completed the trial. There was a significant improvement over time on drinking days,
SADD and OCDS scores in all groups (p 0.001). The drinking days comparison between groups did not show
statistical significant difference. The same effect was observed for compulsion (OCDS) and severity of dependence
scale (SADD). The serum levels of PUFAS increased in all the supplemented groups after treatment, although not
significantly.
Conclusions: The oral
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