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the evolution of the dlk1-dio3 imprinted domain in mammalsdlk1-dio3印领域的发展在哺乳动物
PLoS BIOLOGY
The Evolution of the DLK1-DIO3 Imprinted
Domain in Mammals
1 2 2 3 1 4
Carol A. Edwards , Andrew J. Mungall , Lucy Matthews , Edward Ryder , Dionne J. Gray , Andrew J. Pask ,
4 5 2 2 4
Geoffrey Shaw , Jennifer A.M. Graves , Jane Rogers , the SAVOIR consortium, Ian Dunham , Marilyn B. Renfree ,
1*
Anne C. Ferguson-Smith
1 Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom, 2 Wellcome Trust Sanger Institute, Wellcome Trust
Genome Campus, Hinxton, Cambridge, United Kingdom, 3 Department of Genetics, University of Cambridge, Cambridge, United Kingdom, 4 Department of Zoology,
University of Melbourne, Victoria, Australia, 5 Research School of Biological Sciences, The Australian National University, Canberra, Australia
A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those
that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA
methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and
prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the
divergence of eutherian from marsupial mammals and in eutherians is under strong purifying selection. The marsupial
locus at 1.6 megabases, is double that of eutherians due to the accumulation of LINE repeats. Comparative sequence
analysis o
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