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the expansion of the prame gene family in eutheria在真兽亚纲的扩张prame基因家族
The Expansion of the PRAME Gene Family in Eutheria
1,2 1¤ 3 4 4 1,2
Ti-Cheng Chang , Yang Yang , Hiroshi Yasue , Arvind K. Bharti , Ernest F. Retzel , Wan-Sheng Liu *
1 Department of Dairy and Animal Science, The Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University
Park, Pennsylvania, United States of America, 2 The Integrative Biosciences Program, Bioinformatics and Genomics Option, The Huck Institute of Life Sciences, The
Pennsylvania State University, University Park, Pennsylvania, United States of America, 3 National Institute of Agrobiological Sciences, Tsukuba, Japan, 4 National Center
for Genome Resources, Santa Fe, New Mexico, United States of America
Abstract
The PRAME gene family belongs to the group of cancer/testis genes whose expression is restricted primarily to the testis
and a variety of cancers. The expansion of this gene family as a result of gene duplication has been observed in primates
and rodents. We analyzed the PRAME gene family in Eutheria and discovered a novel Y-linked PRAME gene family in bovine,
PRAMEY, which underwent amplification after a lineage-specific, autosome-to-Y transposition. Phylogenetic analyses
revealed two major evolutionary clades. Clade I containing the amplified PRAMEYs and the unamplified autosomal
homologs in cattle and other eutherians is under stronger functional constraints; whereas, Clade II containing the amplified
autosomal PRAMEs is under positive selection. Deep-sequencing analysis indicated that eight of the identified 16 PRAMEY
loci are active transcrip
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