the early prevention of obesity in children (epoch) collaboration - an individual patient data prospective meta-analysis肥胖儿童的早期预防(时代)合作u2014u2014个体患者数据潜在的荟萃分析.pdfVIP

Askie et al. BMC Public Health 2010, 10:728 /1471-2458/10/728 STUDY PROTOCOL Open Access The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis 1* 2 3 4 3 5 Lisa M Askie , Louise A Baur , Karen Campbell , Lynne A Daniels , Kylie Hesketh , Anthea Magarey , Seema Mihrshahi4 6 1 7 8 1 6 , Chris Rissel , John Simes , Barry Taylor , Rachael Taylor , Merryn Voysey , Li Ming Wen , EPOCH Collaboration1 Abstract Background: Efforts to prevent the development of overweight and obesity have increasingly focused early in the life course as we recognise that both metabolic and behavioural patterns are often established within the first few years of life. Randomised controlled trials (RCTs) of interventions are even more powerful when, with forethought, they are synthesised into an individual patient data (IPD) prospective meta-analysis (PMA). An IPD PMA is a unique research design where several trials are identified for inclusion in an analysis before any of the individual trial results become known and the data are provided for each randomised patient. This methodology minimises the publication and selection bias often associated with a retrospective meta-analysis by allowing hypotheses, analysis methods and selection criteria to be specified a priori. Methods/Design: The Early Prevention of Obesity in CHildren (EPOCH) Collaboration was formed in 2009. The main objective of the EPOCH Collaboration is to determine if early intervention for childhood obesity impacts on body mass index (BMI) z scores at age 18-24 months. Additional res