the comparison between circadian oscillators in mouse liver and pituitary gland reveals different integration of feeding and light schedules昼夜振荡器之间的比较小鼠肝脏和脑垂体显示不同的喂养和集成光时间表.pdfVIP
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the comparison between circadian oscillators in mouse liver and pituitary gland reveals different integration of feeding and light schedules昼夜振荡器之间的比较小鼠肝脏和脑垂体显示不同的喂养和集成光时间表
The Comparison between Circadian Oscillators in Mouse
Liver and Pituitary Gland Reveals Different Integration of
Feeding and Light Schedules
Isabelle M. Bur1,2,3¤, Sonia Zouaoui1,2,3, Pierre Fontanaud1,2,3, Nathalie Coutry1,2,3, Franc¸ois Molino1,2,3,
` 1,2,3, Patrice Mollard1,2,3, Xavier Bonnefont1,2,3*
Agnes O. Martin
´ ´
1 CNRS, UMR 5203, Institut de Genomique Fonctionnelle, Montpellier, France, 2 INSERM, U661, Montpellier, France, 3 Universite Montpellier, Montpellier, France
Abstract
The mammalian circadian system is composed of multiple peripheral clocks that are synchronized by a central pacemaker in
the suprachiasmatic nuclei of the hypothalamus. This system keeps track of the external world rhythms through
entrainment by various time cues, such as the light-dark cycle and the feeding schedule. Alterations of photoperiod and
meal time modulate the phase coupling between central and peripheral oscillators. In this study, we used real-time
quantitative PCR to assess circadian clock gene expression in the liver and pituitary gland from mice raised under various
photoperiods, or under a temporal restricted feeding protocol. Our results revealed unexpected differences between both
organs. Whereas the liver oscillator always tracked meal time, the pituitary circadian clockwork showed an intermediate
response, in between entrainment by the light regimen and the feeding-fasting rhythm. The same composite response was
also observed in the pituitary gland from adrenalectomized mice under daytime restricted feeding, suggesting that
circulating glucocorticoids do not inhibit full entrainment of the pituitary clockwork by meal tim
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