原创力文档the factors influencing depression endpoints research (finder) study final results of italian patients with depression端点抑郁影响因素研究(仪)研究意大利抑郁症患者的最终结果.pdfVIP
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the factors influencing depression endpoints research (finder) study final results of italian patients with depression端点抑郁影响因素研究(仪)研究意大利抑郁症患者的最终结果
Caruso et al. Annals of General Psychiatry 2010, 9:33
/content/9/1/33
PRIMARY RESEARCH Open Access
The Factors Influencing Depression Endpoints
Research (FINDER) study: final results of Italian
patients with depression
1 2 2 3 1,4*
Rosangela Caruso , Andrea Rossi , Alessandra Barraco , Deborah Quail , Luigi Grassi ,
Italian FINDER study group1
Abstract
Background: Factors Influencing Depression Endpoints Research (FINDER) is a 6-month, prospective, observational
study carried out in 12 European countries aimed at investigating health-related quality of life (HRQoL) in
outpatients receiving treatment for a first or new depressive episode. The Italian HRQoL data at 6 months is
described in this report, and the factors associated with HRQoL changes were determined.
Methods: Data were collected at baseline, 3 and 6 months of treatment. HRQoL was measured using components
of the 36-item Short Form Health Survey (SF-36; mental component summary (MCS), physical component summary
(PCS)) and the European Quality of Life-5 Dimensions (EQ-5D; visual analogue scale (VAS) and health status index
(HSI)). The Hospital Anxiety and Depression Scale (HADS) was adopted to evaluate depressive symptoms, while
somatic and painful physical symptoms were assessed by using the 28-item Somatic Symptom Inventory (SSI-28)
and a VAS.
Results: Of the initial 513 patients, 472 completed the 3-month observation and 466 the 6-month observation. The
SF-36 and EQ-5D mean (± SD) scores showed HRQoL improvements at 3 months and a further smaller
improvement at 6 months, with the most positive effects for SF-36 MCS (baseline 22.0 ± 9.2, 3 months 34.6 ± 10.0;
6 months 39.3 ± 9.5) and EQ-5D HSI (baseline 0.4 ± 0.3; 3 months 0.7 ± 0.3;
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