the first nosocomial outbreak of methicillin-resistant staphylococcus aureus in horses in sweden第一医院爆发的耐甲氧西林金黄色葡萄球菌在马在瑞典.pdfVIP

Bergström et al. Acta Veterinaria Scandinavica 2012, 54:11 /content/54/1/11 RESEARCH Open Access The first nosocomial outbreak of methicillin- resistant Staphylococcus aureus in horses in Sweden 1,3* 2 3 4 3 Karin Bergström , Anna Aspan , Annica Landén , Christopher Johnston and Ulrika Grönlund-Andersson Abstract Background: Methicillin-resistant Staphylococcus aureus (MRSA) in animals is a rare finding in Sweden. In horses, MRSA was first detected in a screening survey in 2007. In 2008, six clinical cases occurred in an equine hospital, indicating an outbreak. Method: All MRSA isolates detected, 11 spa-type t011 and one t064 (n = 12), in infected horses (n = 10) and screening of horses (n = 2) in Sweden from December 2007 to March 2010 were retrospectively analysed with pulsed-field gel electrophoresis (PFGE) using Cfr9I and Apa I restriction enzymes, to study relationship between the isolates. Medical records of infected horses and outbreak investigation notes were scrutinised to monitor the clinical outcome and other aspects of the outbreak. Results: Eight of the 10 infected horses were linked to one equine hospital and two to another hospital in the same region. The six horses infected with MRSA in 2008 underwent surgery during the period 22 May-7 July in one of the hospitals. Four more infections linked to the two hospitals were notified between 2009 and March 2010. Nine of the 11 spa-type t011 isolates had identical Cfr9I and Apa I PFGE pattern. All six infected horses from 2008 presented with this MRSA. Two t011 isolates differed in one and two bands, respectively, in PFGE. Nine horses suffered from surgical site infections (SSI). No antimicrobials were use