the effect of long-running severe selenium-deficiency on the amount of iron and zinc in the organs of rats长期严重缺硒的影响对铁和锌的数量在老鼠的器官.pdfVIP
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the effect of long-running severe selenium-deficiency on the amount of iron and zinc in the organs of rats长期严重缺硒的影响对铁和锌的数量在老鼠的器官
Molecules 2009, 14, 4440-4453; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
The Effect of Long-Running Severe Selenium-Deficiency on the
Amount of Iron and Zinc in the Organs of Rats
1,2 1 1 1 1
Ken-ichiro Matsumoto , Sachiyo Terada , Marie Ariyoshi , Aya Okajo , Atsushi Hisamatsu ,
Iori Ui 1 and Kazutoyo Endo 1,*
1 Department of Physical Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-
Tamagawagakuen, Machida-shi, Tokyo 194-8543, Japan; E-Mail: matsumok@nirs.go.jp (K.M.)
2 Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National
Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan
* Author to whom correspondence should be addressed; E-Mail: kazutoyo@ac.shoyaku.ac.jp;
Tel.: +81-42-721-1565; Fax: +81-42-721-1541.
Received: 5 October 2009; in revised form: 2 November 2009 / Accepted: 4 November 2009 /
Published: 5 November 2009
Abstract: The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and
spleen as a function of age of rats measured using instrumental neutron activation analysis
were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can
live for more than 50 weeks. The effect of Se-deficinecy in rats might be weak, compared
to the marked malfunction of GSH-Px. The SeD rats can be considered as a model of non-
lethal c
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