the human polyoma jc virus agnoprotein acts as a viroporin人类多瘤agnoprotein充当viroporin jc病毒.pdfVIP

The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin 1¤ 1,2 3 4 1 5 Tadaki Suzuki , Yasuko Orba , Yuki Okada , Yuji Sunden , Takashi Kimura , Shinya Tanaka , Kazuo 5 6 1,2 Nagashima , William W. Hall , Hirofumi Sawa * 1 Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan, 2 Global COE Program for Zoonosis Control, Hokkaido University, Sapporo, Japan, 3 Career-Path Promotion Unit for Young Life Scientists, ICDO, Kyoto University, Kyoto, Japan, 4 Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine, Sapporo, Japan, 5 Laboratory of Cancer Research, Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan, 6 Centre for Research in Infectious Diseases, University College Dublin, Dublin, Ireland Abstract Virus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability. Viroporins are a group of proteins that interact with plasma membranes modifying permeability and can promote the release of viral particles. While these proteins are not essential for virus replication, their activity certainly promotes virus growth. Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease resulting from lytic infection of oligodendrocytes by the polyomavirus JC virus (JCV). The genome of JCV encodes six major proteins including a small auxiliary protein known as agnoprotein. Studies on other polyomavirus agnoproteins have suggested that the prote