原创力文档the impact of gpx1 on the association of groundwater selenium and depression a project frontier studygpx1影响地下水协会硒和抑郁的一个项目前沿研究.pdfVIP
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the impact of gpx1 on the association of groundwater selenium and depression a project frontier studygpx1影响地下水协会硒和抑郁的一个项目前沿研究
Johnson et al. BMC Psychiatry 2013, 13:7
/1471-244X/13/7
RESEARCH ARTICLE Open Access
The impact of GPX1 on the association of
groundwater selenium and depression: a project
FRONTIER study
1* 2 2 3 4 5
Leigh A Johnson , Jack A Phillips , Cortney Mauer , Melissa Edwards , Valerie Hobson Balldin , James R Hall ,
6 7 8 9
Robert Barber , Tori L Conger , Eric J Ho and Sid E O’Bryant
Abstract
Background: Prior animal model and human-based studies have linked selenium concentrations to decreased risk
for depression; however, this work has not focused on household groundwater levels or specific depressive
symptoms. The current study evaluated the link between groundwater selenium levels and depression. We also
sought to determine if a functional polymorphism in the glutathione peroxidase 1 (GPX1) gene impacted this link.
Methods: We used a cross-sectional design to analyze data from 585 participants (183 men and 402 women) from
Project FRONTIER, a study of rural health in West Texas. Residential selenium concentrations were estimated using
Geospatial Information System (GIS) analyses. Linear regression models were created using Geriatric Depression
Scale (GDS-30) total and subfactor scores as outcome variables and selenium concentrations as predictor variables.
Analyses were re-run after stratification of the sample on GPX1 Pro198Leu genotype (rs1050454).
Results: Selenium levels were significantly and negatively related to all GDS and subfactor scores accounting for up
to 17% of the variance beyond covariates. Selenium was most strongly protective against depression among
homozygous carriers of the C allele at the
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