the functional interaction between acyl-coa synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth a novel therapeutic target酰coa合成酶4之间的功能互动,5-lipooxygenase和cyclooxygenase-2控制肿瘤生长一个新颖的治疗目标.pdfVIP

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the functional interaction between acyl-coa synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth a novel therapeutic target酰coa合成酶4之间的功能互动,5-lipooxygenase和cyclooxygenase-2控制肿瘤生长一个新颖的治疗目标.pdf

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the functional interaction between acyl-coa synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth a novel therapeutic target酰coa合成酶4之间的功能互动,5-lipooxygenase和cyclooxygenase-2控制肿瘤生长一个新颖的治疗目标

The Functional Interaction between Acyl-CoA Synthetase 4, 5-Lipooxygenase and Cyclooxygenase-2 Controls Tumor Growth: A Novel Therapeutic Target 1 2 2 1 ´ 1 Ulises D. Orlando , Juan Garona , Giselle V. Ripoll , Paula M. Maloberti , Angela R. Solano , 3 2 2 ´ 1 Alejandra Avagnina , Daniel E. Gomez , Daniel F. Alonso , Ernesto J. Podesta * ´ 1 Instituto de Investigaciones Biomedicas (INBIOMED), Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina, ´ 2 Laboratory of Molecular Oncology, Quilmes National University, Buenos Aires, Argentina, 3 Pathology Unit, Hospital Universitario-Centro de Estudios Medicos e ´ ´ Investigacion Clınica (CEMIC), Buenos Aires, Argentina Abstract The acyl-CoA synthetase 4 (ACSL4), which esterify mainly arachidonic acid (AA) into acyl-CoA, is increased in breast, colon and hepatocellular carcinoma. The transfection of MCF-7 cells with ACSL4 cDNA transforms the cells into a highly aggressive phenotype and controls both lipooxygenase-5 (LOX-5) and cyclooxygenase-2 (COX-2) metabolism of AA, suggesting a causal role of ACSL4 in tumorigenesis. We hypothesized that ACSL4, LOX-5 and COX-2 may constitute potential therapeutic targets for the control of tumor growth. Therefore, the aim of this study was to use a tetracycline Tet-Off system of MC