原创力文档ubiquitous [na+]i[k+]i-sensitive transcriptome in mammalian cells evidence for ca2+i-independent excitation-transcription coupling无处不在的[na +]我[k +]i-sensitive在哺乳动物细胞中转录组证据ca2 + i-independent excitation-transcription耦合.pdfVIP
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ubiquitous[na]i[k]i-sensitivetranscriptomeinmammaliancellsevidenceforca2i-independentexcitation-transcriptioncoupling无处不在的[na]我[k]i-sensitive在哺乳动物细胞中转录组证据ca2i-independentexcitation-transcription耦合
+ +
Ubiquitous [Na ] /[K ] -Sensitive Transcriptome in
i i
Mammalian Cells: Evidence for Ca2+i-Independent
Excitation-Transcription Coupling
1,2 3 1 2,3 1,4
Svetlana V. Koltsova , Yulia Trushina , Mounsif Haloui , Olga A. Akimova , Johanne Tremblay ,
Pavel Hamet1,4, Sergei N. Orlov1,4*
´ ´ ˆ
1 Centre de recherche, Centre hospitalier de l’Universite de Montreal (CRCHUM) – Technopole Angus, Montreal, PQ, Canada, 2 Institute of General Pathology and
Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia, 3 Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 4 Department of
´ ´
Medicine, Universite de Montreal, Montreal, PQ, Canada
Abstract
Stimulus-dependent elevation of intracellular Ca2+ ([Ca2+] ) affects the expression of numerous genes – a phenomenon
i
known as excitation-transcription coupling. Recently, we found that increases in [Na+] trigger c-Fos expression via a novel
i
2+ + +
Ca -independent pathway. In
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