ubr2 of the n-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cellsubr2 n-end法则的途径是通过组蛋白染色体稳定所需ubiquitylation精母细胞和体细胞.pdfVIP

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ubr2 of the n-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cellsubr2 n-end法则的途径是通过组蛋白染色体稳定所需ubiquitylation精母细胞和体细胞.pdf

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ubr2 of the n-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cellsubr2 n-end法则的途径是通过组蛋白染色体稳定所需ubiquitylation精母细胞和体细胞

UBR2 of the N-End Rule Pathway Is Required for Chromosome Stability via Histone Ubiquitylation in Spermatocytes and Somatic Cells 1¤ 2 1 2 2 2 Jee Young An , Euna Kim , Adriana Zakrzewska , Young Dong Yoo , Jun Min Jang , Dong Hoon Han , 3 1 4 2,5 6 7 Min Jae Lee , Jai Wha Seo , Yong Jun Lee , Tae-You Kim , Dirk G. de Rooij , Bo Yeon Kim *, Yong Tae Kwon1,2* 1 Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 2 World Class University (WCU) Program, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Korea, 3 Department of Applied Chemistry, College of Applied Sciences, Kyung Hee University, Yongin, Korea, 4 Department of Surgery and Pharmacology, School of Medicine, University of Pittsburgh, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America, 5 Seoul National University Cancer Hospital and College of Medicine, Seoul, Korea, 6 Reproductive Biology Laboratory, Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, 7 World Class Institute, Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Korea Abstract The N-end rule pathway is a proteolytic system in which its recognition components (N-recognins) recognize destabilizing N-terminal residues