the group delay and suppression pattern of the cochlear microphonic potential recorded at the round window的群延迟和抑制模式耳蜗微音器电位记录在圆窗口.pdfVIP

The Group Delay and Suppression Pattern of the Cochlear Microphonic Potential Recorded at the Round Window 1 1 2 1 1 Wenxuan He , Edward Porsov , David Kemp , Alfred L. Nuttall , Tianying Ren * 1 Department of Otolaryngology and Head and Neck Surgery, Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America, 2 UCL Ear Institute, University College, London, United Kingdom Abstract Background: It is commonly assumed that the cochlear microphonic potential (CM) recorded from the round window (RW) is generated at the cochlear base. Based on this assumption, the low-frequency RW CM has been measured for evaluating the integrity of mechanoelectrical transduction of outer hair cells at the cochlear base and for studying sound propagation inside the cochlea. However, the group delay and the origin of the low-frequency RW CM have not been demonstrated experimentally. Methodology/Principal Findings: This study quantified the intra-cochlear group delay of the RW CM by measuring RW CM and vibrations at the stapes and basilar membrane in gerbils. At low sound levels, the RW CM showed a significant group delay and a nonlinear growth at frequencies below 2 kHz. However, at high sound levels or at frequencies above 2 kHz, the RW CM magnitude increased proportionally with sound pressure, and the CM phase in respect to the stapes showed no significant group delay. After the local application of tetrodotoxin the RW CM below 2 kHz became linear and showed a negligible group delay. In contrast to RW CM phase, the BM vibration measured at location ,2.5 mm from the base showed high sensitivity, sharp tuning, and nonlinearity with a frequency-dependent group delay. At low or intermediate sound levels, low-frequency