原创力文档the er-bound ring finger protein 5 (rnf5rma1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositiser-bound无名指蛋白5(rnf5rma1)导致转基因小鼠和退行性肌病是包涵体肌炎管制.pdfVIP
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the er-bound ring finger protein 5 (rnf5rma1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositiser-bound无名指蛋白5(rnf5rma1)导致转基因小鼠和退行性肌病是包涵体肌炎管制
The ER-Bound RING Finger Protein 5 (RNF5/RMA1)
Causes Degenerative Myopathy in Transgenic Mice and
Is Deregulated in Inclusion Body Myositis
` 1 2 3 4 1
Agnes Delaunay , Kenneth D. Bromberg , Yukiko Hayashi , Massimiliano Mirabella , Denise Burch ,
1 1 3 5 4
Brian Kirkwood , Carlo Serra , May C. Malicdan , Andrew P. Mizisin , Roberta Morosetti , Aldobrando
4 5 6 7 1,8 5
Broccolini , Ling T. Guo , Stephen N. Jones , Sergio A. Lira , Pier Lorenzo Puri , G. Diane Shelton ,
Ze’ev Ronai1*
1 Signal Transduction, The Burnham Institute for Medical Research, La Jolla, California, United States of America, 2 Department of Pharmacology and Systems
Therapeutics, Mount Sinai School of Medicine, New York, New York, United States of America, 3 National Institute of Neuroscience, Tokyo, Japan, 4 Department of
Neuroscience, Catholic University, Rome, Italy, 5 Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of
America, 6 Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, 7 Immunobiology Center, Mount
Sinai School of Medicine, New York, New York, United States of America, 8 Dulbecco Telethon Institute at Fondazione European Brain Research Institute (EBRI)/S.Lucia
00134, Rome, Italy
Abstract
Growing evidence supports the importance of ubiquitin ligases in the pathogenesis of muscular disorders, although
underlying
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