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the ess rat, a nonobese model of disordered glucose and lipid metabolism and fatty liveress老鼠,nonobese模型葡萄糖和脂质代谢紊乱和脂肪肝
Daniele et al. Diabetology Metabolic Syndrome 2010, 2:15
DIABETOLOGY
/content/2/1/15
METABOLIC SYNDROME
RESEARCH Open Access
The eSS rat, a nonobese model of disordered
glucose and lipid metabolism and fatty liver
Stella M Daniele1†, Silvana M Montenegro2,3†, María C Tarres2,3†, Juan C Picena2†, Stella M Martinez2,3*
Abstract
Background: eSS is a rat model of type 2 diabetes characterized by fasting hyperglycemia, glucose intolerance,
hyperinsulinemia and early hypertriglyceridemia. Diabetic symptoms worsen during the second year of life as
insulin release decreases. In 12-month-old males a diffuse hepatic steatosis was detected. We report the
disturbances of lipid metabolism of the model with regard to the diabetic syndrome.
Methods: The study was conducted in eight 12-month-old eSS male rats and seven age/weight matched
eumetabolic Wistar rats fed with a complete commercial diet al libitum. Fasting plasmatic glucose, insulin,
triglycerides, total cholesterol, low-density and high-density lipoprotein, and nonesterified fatty acids levels were
measured. Very low density and intermediate-density lipoproteins were analyzed and hepatic lipase activity was
determined.
Results: eSS rats developed hyperglycemia and hyperinsulinemia, indicating insulin resistance. Compared with
controls, diabetic rats exhibited high plasmatic levels of NEFA, triglycerides (TG), total cholesterol (Chol) and LDL-
Chol while high-density lipoprotein (HDL) cholesterol values were reduced. eSS rats also displayed TG-rich VLDL
and IDL particles without changes in hepatic lipase activity.
Conclusion: The nonobese eSS rats dev
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