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The Dopamine Augmenter L-DOPA Does Not Affect Positive Mood in Healthy Human Volunteers John Liggins, Robert O. Pihl, Chawki Benkelfat, Marco Leyton* ´ ´ Department of Psychiatry, McGill University, Montreal, Quebec, Canada Abstract Dopamine neurotransmission influences approach toward rewards and reward-related cues. The best cited interpretation of this effect proposes that dopamine mediates the pleasure that commonly accompanies reward. This hypothesis has received support in some animal models and a few studies in humans. However, direct assessments of the effect of transiently increasing dopamine neurotransmission have been largely limited to the use of psychostimulant drugs, which elevate brain levels of multiple neurotransmitters in addition to dopamine. In the present study we tested the effect of more selectively elevating dopamine neurotransmission, as produced by administration of the immediate dopamine precursor, L- DOPA (0, 100/25, 200/50 mg, Sinemet), in healthy human volunteers. Neither dose altered positive mood. The results suggest that dopamine neurotransmission does not directly influence positive mood in humans. Citation: Liggins J, Pihl RO, Benkelfat C, Leyton M (2012) The Dopamine Augmenter L-DOPA Does Not Affect Positive Mood in Healthy Human Volunteers. PLoS ONE 7(1): e28370. doi:10.1371/journal.pone.0028370 Editor: Bernard Le Foll, Centre for Addiction and Mental Health, Canada Received July 1, 2011; Accepted November 7, 2011; Published January 4, 2012 Copyright: 2012 Liggins et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This w