原创力文档the chromosomal passenger complex activates polo kinase at centromeres在着丝粒染色体乘客复杂激活马球激酶.pdfVIP
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the chromosomal passenger complex activates polo kinase at centromeres在着丝粒染色体乘客复杂激活马球激酶
The Chromosomal Passenger Complex Activates Polo
Kinase at Centromeres
1 2 1 2 1 1
Mar Carmena *, Xavier Pinson , Melpi Platani , Zeina Salloum , Zhenjie Xu , Anthony Clark , Fiona
1 1 3 4 2,5
MacIsaac , Hiromi Ogawa , Ulrike Eggert , David M. Glover , Vincent Archambault *, William C.
Earnshaw1
´
1 Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, United Kingdom, 2 Institut de Recherche en Immunologie et en Cancerologie,
´ ´ ´ ´
Universite de Montreal, Montreal, Quebec, Canada, 3 Dana-Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical
School, Boston, Massachusetts, United States, 4 Cancer Research UK, Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Cambridge,
´ ´ ´ ´ ´
United Kingdom, 5 Departement de Biochimie, Universite de Montreal, Montreal, Quebec, Canada
Abstract
The coordinated activities at centromeres of two key cell cycle kinases, Polo and Aurora B, are critical for ensuring that the
two sister kinetochores of each chromosome are attached to microtubules from opposite spindle poles prior to
chromosome segregation at anaphase. Initial attachments of chromosomes to the spindle involve random interactions
between kineto
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