原创力文档the chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues染色体9 . 3冠心病风险等位基因与正常心脏和血管组织中基因表达改变.pdfVIP
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the chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues染色体9 . 3冠心病风险等位基因与正常心脏和血管组织中基因表达改变
The Chromosome 9p21.3 Coronary Heart Disease Risk
Allele Is Associated with Altered Gene Expression in
Normal Heart and Vascular Tissues
1 2 3 4 4
Anna P. Pilbrow *, Lasse Folkersen , John F. Pearson , Chris M. Brown , Les McNoe , Nancy M. Wang,
5 5 4 1 1
Wendy E. Sweet , W. H. Wilson Tang , Michael A. Black , Richard W. Troughton , A. Mark Richards ,
6 2 2 5 1
Anders Franco-Cereceda , Anders Gabrielsen , Per Eriksson , Christine S. Moravec , Vicky A. Cameron
1 Christchurch Cardioendocrine Research Group, Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand, 2 Department of Medicine,
Karolinska Institutet, Stockholm, Sweden, 3 Department of Public Health and General Practice, University of Otago Christchurch, Christchurch, New Zealand, 4 Department
of Biochemistry, University of Otago, Dunedin, New Zealand, 5 Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland,
Ohio, United States of America, 6 Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Abstract
Genome-wide association studies have identified a coronary artery disease (CAD) risk locus in a non-coding region at
9p21.3, the nearest genes being CDKN2A and CDKN2B. To understand the pathways by which this locus might influence
CAD susceptibility, we investigated associations between the 9p21.3 risk genotype and global gene expression in heart
tissue from donors with no diagnosed
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