原创力文档the cinnamon-derived dietary factor cinnamic aldehyde activates the nrf2-dependent antioxidant response in human epithelial colon cells肉桂醛的cinnamon-derived膳食因素激活nrf2-dependent人类结肠上皮细胞抗氧化反应.pdfVIP
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the cinnamon-derived dietary factor cinnamic aldehyde activates the nrf2-dependent antioxidant response in human epithelial colon cells肉桂醛的cinnamon-derived膳食因素激活nrf2-dependent人类结肠上皮细胞抗氧化反应
Molecules 2010, 15, 3338-3355; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde
Activates the Nrf2-Dependent Antioxidant Response in Human
Epithelial Colon Cells
Georg Thomas Wondrak †,*, Nicole F. Villeneuve †, Sarah D. Lamore, Alexandra S. Bause,
Tao Jiang and Donna D. Zhang *
Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center,
University of Arizona, Tucson, AZ 85724, USA; E-Mails: nvillene@ (N.F.V.);
lamore@ (S.D.L.); Alexandra_Bause@ (A.S.B.);
tjiang@ (T.J.)
† These two authors contributed equally to this study.
* Authors to whom correspondence should be addressed; E-Mail: wondrak@
(G.T.W.); dzhang@ (D.D.Z.).
Received: 24 March 2010; in revised form: 27 April 2010 / Accepted: 6 May 2010 /
Published: 7 May 2010
Abstract: Colorectal cancer (CRC) is a major cause of tumor-related morbidity and
mortality worldwide. Recent research suggests that pharmacological intervention using
dietary factors that activate the redox sensitive Nrf2/Keap1-ARE signaling pathway may
represent a promising strategy for chemoprevention of human cancer including CRC. In
our search for dietary Nrf2 activators with potential chemopreventive activity targeting
CRC, we have focused our studies on trans-cinnamic aldehyde (cinnamaldeyde, CA), the
key flavor compound in cinnamon essential oil. Here we demonstrate that CA and an
ethanolic extract (CE) prepar
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