原创力文档the escherichia coli btue protein functions as a resistance determinant against reactive oxygen species大肠杆菌btue蛋白功能作为一个电阻对活性氧行列式.pdfVIP
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the escherichia coli btue protein functions as a resistance determinant against reactive oxygen species大肠杆菌btue蛋白功能作为一个电阻对活性氧行列式
The Escherichia coli BtuE Protein Functions as a
Resistance Determinant against Reactive Oxygen Species
1 1 1 ´ ´ 1 2
Felipe A. Arenas , Paulo C. Covarrubias , Juan M. Sandoval , Jose M. Perez-Donoso , James A. Imlay ,
´ 1*
Claudio C. Vasquez
´ ´ ´
1 Departamento de Biologıa, Facultad de Quımica y Biologıa, Universidad de Santiago de Chile, Santiago, Chile, 2 Department of Microbiology, University of Illinois,
Urbana-Champaign, Illinois, United States of America
Abstract
This work shows that the recently described Escherichia coli BtuE peroxidase protects the bacterium against oxidative stress
that is generated by tellurite and by other reactive oxygen species elicitors (ROS). Cells lacking btuE (DbtuE) displayed higher
sensitivity to K2TeO3 and other oxidative stress-generating agents than did the isogenic, parental, wild-type strain. They also
exhibited increased levels of cytoplasmic reactive oxygen species, oxidized proteins, thiobarbituric acid reactive substances,
and lipoperoxides. E. coli DbtuE that was exposed to tellurite or H2O2 did not show growth changes relative to wild type
cells either in aerobic or anaerobic conditions. Nevertheless, the elimination of btuE from cells deficient in catalases/
peroxidases (Hpx2) resulted in impaired growth and resistance to these toxicants only in aerobic conditions, suggesting
that BtuE is involved in the defense against oxidative damage. Genetic complementation of E. coli DbtuE restored toxicant
resistance to levels exhibited by the wild type strain. As expected, btuE overexpression resulted in decreased amounts of
oxidative damage products as w
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