ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of tramp mice by modulating pro-inflammatory pathways乌索酸抑制起始,前列腺癌的进展,延长生存的流浪汉老鼠通过调节炎性通路.pdfVIP

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ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of tramp mice by modulating pro-inflammatory pathways乌索酸抑制起始,前列腺癌的进展,延长生存的流浪汉老鼠通过调节炎性通路.pdf

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ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of tramp mice by modulating pro-inflammatory pathways乌索酸抑制起始,前列腺癌的进展,延长生存的流浪汉老鼠通过调节炎性通路

Ursolic Acid Inhibits the Initiation, Progression of Prostate Cancer and Prolongs the Survival of TRAMP Mice by Modulating Pro-Inflammatory Pathways 1 2 1,3,4 5 5 Muthu K. Shanmugam , Tina H. Ong , Alan Prem Kumar , Chang K. Lun , Paul C. Ho , Peter T. H. 1 2 1,3 Wong , Kam M. Hui *, Gautam Sethi * 1 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 2 Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore, Singapore, 3 Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, 4 School of Anatomy and Human Biology, The University of Western Australia, Crawley, Perth, Western Australia, Australia, 5 Department of Pharmacy, National University of Singapore, Singapore, Singapore Abstract Prostate cancer is one of the leading causes of cancer death among men worldwide. In this study, using transgenic adenocarcinoma of mouse prostate (TRAMP) mice, the effect of diet enriched with 1% w/w ursolic acid (UA) was investigated to evaluate the stage specific chemopreventive activity against prostate cancer. We found that TRAMP mice fed with UA diet for 8 weeks (weeks 4 to 12) delayed formation of prostate intraepithelial neoplasia (PIN). Similarly, mice fed with UA diet for 6 weeks (weeks 12 to 18) inhibited progression of PIN to adenocarcinoma as determined by hematoxylin and eosin staining. Finally, TRAMP mice fed with UA diet for 12 weeks (weeks 24 to 36) demonstrated markedly reduced tumor growth without