原创力文档vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cellsvaccinia-related激酶1所需的维护未分化spermatogonia在小鼠雄性生殖细胞.pdfVIP
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vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cellsvaccinia-related激酶1所需的维护未分化spermatogonia在小鼠雄性生殖细胞
Vaccinia-Related Kinase 1 Is Required for the
Maintenance of Undifferentiated Spermatogonia in
Mouse Male Germ Cells
1 1 1 2 2 2
Yoon Ha Choi , Choon-Ho Park , Wanil Kim , Hua Ling , Aram Kang , Matthew Wook Chang ,
1 1 3 1,4
Sun-Kyoung Im , Hyun-Woo Jeong , Young-Yun Kong , Kyong-Tai Kim *
1 Division of Molecular and Life Science, Department of Life Science, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea, 2 School of
Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore, 3 Department of Biological Sciences, Seoul National University, Seoul,
Republic of Korea, 4 Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
Abstract
Vaccinia-related kinase 1 (VRK1) is a crucial protein kinase for mitotic regulation. VRK1 is known to play a role in germ cell
development, and its deficiency results in sterility. Here we describe that VRK1 is essential for the maintenance of
spermatogonial stem cells. To determine whether VRK1 plays a role in these cells, we assessed the population size of
undifferentiated spermatogonia. Flow cytometry analyses showed that the number of undifferentiated spermatogonia was
markedly reduced in VRK1-deficient testes. VRK1 was highly expressed in spermatogonial populations, and approximately
66% of undifferentiated spermatogonia that were sorted as an Ep-CAM+/c-kit 2/alpha-6-integrin+ population showed a
positive signal for VRK1. Undifferentiated stem cells
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