原创力文档variations in the hemagglutinin of the 2009 h1n1 pandemic virus potential for strains with altered virulence phenotype2009年h1n1流感大流行病毒的血凝素的变化可能与改变毒性菌株表型.pdfVIP
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variations in the hemagglutinin of the 2009 h1n1 pandemic virus potential for strains with altered virulence phenotype2009年h1n1流感大流行病毒的血凝素的变化可能与改变毒性菌株表型
Variations in the Hemagglutinin of the 2009 H1N1
Pandemic Virus: Potential for Strains with Altered
Virulence Phenotype?
Jianqiang Ye1,2, Erin M. Sorrell1,2, Yibin Cai1,2, Hongxia Shao1,2, Kemin Xu1,2, Lindomar Pena 1,2, Danielle
1,2 3 1,2 4,5,6 4,5,6
Hickman , Haichen Song , Matthew Angel , Rafael A. Medina , Balaji Manicassamy , Adolfo
Garcia-Sastre4,5,6, Daniel R. Perez1,2*
1Virginia-Maryland Regional College of Veterinary Medicine, College Park, Maryland, United States of America, 2 Department of Veterinary Medicine, University of
Maryland, College Park, Maryland, United States of America, 3 Synbiotics Corporation, College Park, Maryland, United States of America, 4 Department of Microbiology,
Mount Sinai School of Medicine, New York, New York, United States of America, 5 Institute of Global Health and Emerging Pathogens, Mount Sinai School of Medicine,
New York, New York, United States of America, 6 Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, New York, United
States of America
Abstract
A novel, swine-origin influenza H1N1 virus (H1N1pdm) caused the first pandemic of the 21st century. This pandemic,
although efficient in transmission, is mild in virulence. This atypical mild pandemic season has raised concerns regarding the
potential of this virus to acquire additional virulence markers either through further adaptation or possibly by immune
pressure in the human host. Using the mouse model we generated, within a single round of infection with A/California/04/
09/H1N1 (Ca/04), a virus lethal in mice—herein referred to as mouse-adapted Ca/04 (ma-Ca/04). Five amino acid
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