whole-genome immunoinformatic analysis of f. tularensis predicted ctl epitopes clustered in hotspots are prone to elicit a t-cell response全基因组immunoinformatic f .土拉杆菌内ctl表位预测分析集中在热点地区容易引起t细胞反应.pdfVIP

Whole-Genome Immunoinformatic Analysis of F. tularensis: Predicted CTL Epitopes Clustered in Hotspots Are Prone to Elicit a T-Cell Response Anat Zvi, Shahar Rotem, Erez Bar-Haim, Ofer Cohen, Avigdor Shafferman* Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel Abstract The cellular arm of the immune response plays a central role in the defense against intracellular pathogens, such as F. tularensis. To date, whole genome immunoinformatic analyses were limited either to relatively small genome