znf198 stabilizes the lsd1–corest–hdac1 complex on chromatin through its mym-type zinc fingers通过其mym-type znf198稳定lsd1-corest-hdac1复杂在染色质锌手指.pdfVIP

ZNF198 Stabilizes the LSD1–CoREST–HDAC1 Complex on Chromatin through Its MYM-Type Zinc Fingers Christian B. Gocke, Hongtao Yu* Howard Hughes Medical Institute, Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America Abstract Histone modifications in chromatin regulate gene expression. A transcriptional co-repressor complex containing LSD1– CoREST–HDAC1 (termed LCH hereafter for simplicity) represses transcription by coordinately removing histone modi