β subunit m2–m3 loop conformational changes are uncoupled from α1 β glycine receptor channel gating implications for human hereditary hyperekplexiaβ亚基m2-m3循环构象变化分道扬镳α1β甘氨酸受体对人类遗传hyperekplexia通道控制的影响.pdfVIP

b Subunit M2–M3 Loop Conformational Changes Are Uncoupled from a 1 b Glycine Receptor Channel Gating: Implications for Human Hereditary Hyperekplexia 1 1 1,2 Qiang Shan *, Lu Han , Joseph W. Lynch 1 Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia, 2 School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia Abstract Hereditary hyperekplexia, or startle disease, is a neuromotor disorder caused mainly by mutations that either prevent the surfa