γδ t cells are reduced and rendered unresponsive by hyperglycemia and chronic tnfα in mouse models of obesity and metabolic diseaseγδt细胞减少,高血糖症和慢性tnfα呈现响应的肥胖和代谢疾病的小鼠模型.pdfVIP

cd T Cells Are Reduced and Rendered Unresponsive by Hyperglycemia and Chronic TNFa in Mouse Models of Obesity and Metabolic Disease Kristen R. Taylor, Robyn E. Mills, Anne E. Costanzo, Julie M. Jameson* Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America Abstract Epithelial cells provide an initial line of defense against damage and pathogens in barrier tissues such as the skin; however this balance is disrupted in obesity and metabolic disease. Skin cd T cells recognize epithelial damage, and rel