biophysical characterization of the olfactomedin domain of myocilin, an extracellular matrix protein implicated in inherited forms of glaucomamyocilin olfactomedin域的生物物理特性,细胞外基质蛋白涉及遗传形式的青光眼.pdfVIP

Biophysical Characterization of the Olfactomedin Domain of Myocilin, an Extracellular Matrix Protein Implicated in Inherited Forms of Glaucoma Susan D. Orwig, Raquel L. Lieberman* School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States of America Abstract Myocilin is an eye protein found in the trabecular extracellular matrix (TEM), within the anatomic region that controls fluid flow. Variants of myocilin, localized to its olfactomedin (OLF) domain, have been linked to inherited forms of glaucoma, a disease associated