blocking autophagy prevents bortezomib-induced nf-κb activation by reducing i-κbα degradation in lymphoma cells阻断自噬可以防止bortezomib-induced nf-κb激活通过减少i-κbα淋巴瘤细胞的退化.pdfVIP

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2017-09-12 发布于上海
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blocking autophagy prevents bortezomib-induced nf-κb activation by reducing i-κbα degradation in lymphoma cells阻断自噬可以防止bortezomib-induced nf-κb激活通过减少i-κbα淋巴瘤细胞的退化.pdf

blocking autophagy prevents bortezomib-induced nf-κb activation by reducing i-κbα degradation in lymphoma cells阻断自噬可以防止bortezomib-induced nf-κb激活通过减少i-κbα淋巴瘤细胞的退化

Blocking Autophagy Prevents Bortezomib-Induced NF-kB Activation by Reducing I-kBa Degradation in Lymphoma Cells Li Jia*, Ganga Gopinathan, Johanna T. Sukumar, John G. Gribben Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom Abstract Here we show that bortezomib induces effective proteasome inhibition and accumulation of poly-ubiquitinated proteins in diffuse large B-cell lymphoma (DLBCL) cells. This leads to induction of endoplasmic ret

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blocking autophagy prevents bortezomib-induced nf-κb activation by reducing i-κbα degradation in lymphoma cells阻断自噬可以防止bortezomib-induced nf-κb激活通过减少i-κbα淋巴瘤细胞的退化.pdfVIP