deep sequencing reveals direct targets of gammaherpesvirus-induced mrna decay and suggests that multiple mechanisms govern cellular transcript escape深度测序揭示gammaherpesvirus-induced mrna衰变的直接目标,表明多个机制控制细胞转录逃跑.pdfVIP

Deep Sequencing Reveals Direct Targets of Gammaherpesvirus-Induced mRNA Decay and Suggests That Multiple Mechanisms Govern Cellular Transcript Escape Karen Clyde, Britt A. Glaunsinger* Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America Abstract One characteristic of lytic infection with gammaherpesviruses, including Kaposi’s sarcoma-associated herpesvirus (KSHV), Epstein-Barr virus (EBV) and murine herpesvirus 68 (MHV68), is the dramatic suppression of cellular gene expression in a process known as