determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases adam10, bace1 and γ-secretase测定淀粉样前体如蛋白2的蛋白水解乳沟网站由蛋白酶adam10 bace1γ-secretase.pdfVIP
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determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases adam10, bace1 and γ-secretase测定淀粉样前体如蛋白2的蛋白水解乳沟网站由蛋白酶adam10 bace1γ-secretase
Determination of the Proteolytic Cleavage Sites of the
Amyloid Precursor-Like Protein 2 by the Proteases
ADAM10, BACE1 and c-Secretase
Sebastian Hogl1,2, Peer-Hendrik Kuhn1,2, Alessio Colombo1,2, Stefan F. Lichtenthaler1,2*
1 German Center for Neurodegenerative Diseases (DZNE), Munich, Germany, 2 Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, Munich, Germany
Abstract
Regulated intramembrane proteolysis of the amyloid precursor protein (APP) by the protease activities a-, b- and c-
secretase controls the generation
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